itkMultiResolutionPDEDeformableRegistration.txx

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/*=========================================================================

  Program:   Insight Segmentation & Registration Toolkit
  Module:    $RCSfile: itkMultiResolutionPDEDeformableRegistration.txx,v $
  Language:  C++
  Date:      $Date: 2009-01-26 21:45:51 $
  Version:   $Revision: 1.33 $

  Copyright (c) Insight Software Consortium. All rights reserved.
  See ITKCopyright.txt or http://www.itk.org/HTML/Copyright.htm for details.

     This software is distributed WITHOUT ANY WARRANTY; without even 
     the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR 
     PURPOSE.  See the above copyright notices for more information.

=========================================================================*/
#ifndef __itkMultiResolutionPDEDeformableRegistration_txx
#define __itkMultiResolutionPDEDeformableRegistration_txx
#include "itkMultiResolutionPDEDeformableRegistration.h"

#include "itkRecursiveGaussianImageFilter.h"
#include "itkRecursiveMultiResolutionPyramidImageFilter.h"
#include "itkImageRegionIterator.h"
#include "vnl/vnl_math.h"

namespace itk {

template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::MultiResolutionPDEDeformableRegistration()
{
 
  this->SetNumberOfRequiredInputs(2);

  typename DefaultRegistrationType::Pointer registrator =
    DefaultRegistrationType::New();
  m_RegistrationFilter = static_cast<RegistrationType*>(
    registrator.GetPointer() );

  m_MovingImagePyramid  = MovingImagePyramidType::New();
  m_FixedImagePyramid     = FixedImagePyramidType::New();
  m_FieldExpander     = FieldExpanderType::New();
  m_InitialDeformationField = NULL;

  m_NumberOfLevels = 3;
  m_NumberOfIterations.resize( m_NumberOfLevels );
  m_FixedImagePyramid->SetNumberOfLevels( m_NumberOfLevels );
  m_MovingImagePyramid->SetNumberOfLevels( m_NumberOfLevels );

  unsigned int ilevel;
  for( ilevel = 0; ilevel < m_NumberOfLevels; ilevel++ )
    {
    m_NumberOfIterations[ilevel] = 10;
    }
  m_CurrentLevel = 0;

  m_StopRegistrationFlag = false;

}


/*
 * Set the moving image image.
 */
template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
void
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::SetMovingImage(
  const MovingImageType * ptr )
{
  this->ProcessObject::SetNthInput( 2, const_cast< MovingImageType * >( ptr ) );
}


/*
 * Get the moving image image.
 */
template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
const typename MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::MovingImageType *
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::GetMovingImage(void) const
{
  return dynamic_cast< const MovingImageType * >
    ( this->ProcessObject::GetInput( 2 ) );
}


/*
 * Set the fixed image.
 */
template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
void
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::SetFixedImage(
  const FixedImageType * ptr )
{
  this->ProcessObject::SetNthInput( 1, const_cast< FixedImageType * >( ptr ) );
}


/*
 * Get the fixed image.
 */
template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
const typename MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::FixedImageType *
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::GetFixedImage(void) const
{
  return dynamic_cast< const FixedImageType * >
    ( this->ProcessObject::GetInput( 1 ) );
}

/*
 * 
 */
template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
std::vector<SmartPointer<DataObject> >::size_type
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::GetNumberOfValidRequiredInputs() const
{
  typename std::vector<SmartPointer<DataObject> >::size_type num = 0;

  if (this->GetFixedImage())
    {
    num++;
    }

  if (this->GetMovingImage())
    {
    num++;
    }
  
  return num;
}


template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
void
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::SetNumberOfLevels(
  unsigned int num )
{
  if( m_NumberOfLevels != num )
    {
    this->Modified();
    m_NumberOfLevels = num;
    m_NumberOfIterations.resize( m_NumberOfLevels );
    }

  if( m_MovingImagePyramid && m_MovingImagePyramid->GetNumberOfLevels() != num )
    {
    m_MovingImagePyramid->SetNumberOfLevels( m_NumberOfLevels );
    }
  if( m_FixedImagePyramid && m_FixedImagePyramid->GetNumberOfLevels() != num )
    {
    m_FixedImagePyramid->SetNumberOfLevels( m_NumberOfLevels );
    }  
    
}


template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
void
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::PrintSelf(std::ostream& os, Indent indent) const
{
  Superclass::PrintSelf(os, indent);
  os << indent << "NumberOfLevels: " << m_NumberOfLevels << std::endl;
  os << indent << "CurrentLevel: " << m_CurrentLevel << std::endl;

  os << indent << "NumberOfIterations: [";
  unsigned int ilevel;
  for( ilevel = 0; ilevel < m_NumberOfLevels - 1; ilevel++ )
    {
    os << m_NumberOfIterations[ilevel] << ", ";
    }
  os << m_NumberOfIterations[ilevel] << "]" << std::endl;
  
  os << indent << "RegistrationFilter: ";
  os << m_RegistrationFilter.GetPointer() << std::endl;
  os << indent << "MovingImagePyramid: ";
  os << m_MovingImagePyramid.GetPointer() << std::endl;
  os << indent << "FixedImagePyramid: ";
  os << m_FixedImagePyramid.GetPointer() << std::endl;

  os << indent << "FieldExpander: ";
  os << m_FieldExpander.GetPointer() << std::endl;

  os << indent << "StopRegistrationFlag: ";
  os << m_StopRegistrationFlag << std::endl;

}

/*
 * Perform a the deformable registration using a multiresolution scheme
 * using an internal mini-pipeline
 *
 *  ref_pyramid ->  registrator  ->  field_expander --|| tempField
 * test_pyramid ->           |                              |
 *                           |                              |
 *                           --------------------------------
 *
 * A tempField image is used to break the cycle between the
 * registrator and field_expander.
 *
 */
template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
void
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::GenerateData()
{
  // Check for NULL images and pointers
  MovingImageConstPointer movingImage = this->GetMovingImage();
  FixedImageConstPointer  fixedImage = this->GetFixedImage();

  if( !movingImage || !fixedImage )
    {
    itkExceptionMacro( << "Fixed and/or moving image not set" );
    }

  if( !m_MovingImagePyramid || !m_FixedImagePyramid )
    {
    itkExceptionMacro( << "Fixed and/or moving pyramid not set" );
    }

  if( !m_RegistrationFilter )
    {
    itkExceptionMacro( << "Registration filter not set" );
    }

  if( this->m_InitialDeformationField && this->GetInput(0) )
    {
    itkExceptionMacro( << "Only one initial deformation can be given. "
                       << "SetInitialDeformationField should not be used in "
                       << "cunjunction with SetArbitraryInitialDeformationField "
                       << "or SetInput.");
    }
  
  // Create the image pyramids.
  m_MovingImagePyramid->SetInput( movingImage );
  m_MovingImagePyramid->UpdateLargestPossibleRegion();

  m_FixedImagePyramid->SetInput( fixedImage );
  m_FixedImagePyramid->UpdateLargestPossibleRegion();
 
  // Initializations
  m_CurrentLevel = 0;
  m_StopRegistrationFlag = false;

  unsigned int movingLevel = vnl_math_min( (int) m_CurrentLevel, 
                                           (int) m_MovingImagePyramid->GetNumberOfLevels() );

  unsigned int fixedLevel = vnl_math_min( (int) m_CurrentLevel, 
                                          (int) m_FixedImagePyramid->GetNumberOfLevels() );

  DeformationFieldPointer tempField = NULL;

  DeformationFieldPointer inputPtr =
    const_cast< DeformationFieldType * >( this->GetInput(0) );
  
  if ( this->m_InitialDeformationField )
    {
    tempField = this->m_InitialDeformationField;
    }
  else if( inputPtr )
    {
    // Arbitrary initial deformation field is set.
    // smooth it and resample

    // First smooth it
    tempField = inputPtr;
      
    typedef RecursiveGaussianImageFilter< DeformationFieldType,
      DeformationFieldType> GaussianFilterType;
    typename GaussianFilterType::Pointer smoother
      = GaussianFilterType::New();
      
    for (unsigned int dim=0; dim<DeformationFieldType::ImageDimension; ++dim)
      {
      // sigma accounts for the subsampling of the pyramid
      double sigma = 0.5 * static_cast<float>(
        m_FixedImagePyramid->GetSchedule()[fixedLevel][dim] );

      // but also for a possible discrepancy in the spacing
      sigma *= fixedImage->GetSpacing()[dim]
        / inputPtr->GetSpacing()[dim];
      
      smoother->SetInput( tempField );
      smoother->SetSigma( sigma );
      smoother->SetDirection( dim );
      
      smoother->Update();
      
      tempField = smoother->GetOutput();
      tempField->DisconnectPipeline();
      }
      
      
    // Now resample
    m_FieldExpander->SetInput( tempField );
    
    typename FloatImageType::Pointer fi = 
      m_FixedImagePyramid->GetOutput( fixedLevel );
    m_FieldExpander->SetSize( 
      fi->GetLargestPossibleRegion().GetSize() );
    m_FieldExpander->SetOutputStartIndex(
      fi->GetLargestPossibleRegion().GetIndex() );
    m_FieldExpander->SetOutputOrigin( fi->GetOrigin() );
    m_FieldExpander->SetOutputSpacing( fi->GetSpacing());
    m_FieldExpander->SetOutputDirection( fi->GetDirection());

    m_FieldExpander->UpdateLargestPossibleRegion();
    m_FieldExpander->SetInput( NULL );
    tempField = m_FieldExpander->GetOutput();
    tempField->DisconnectPipeline();
    }

  bool lastShrinkFactorsAllOnes = false;

  while ( !this->Halt() )
    {
   
    if( tempField.IsNull() )
      {
      m_RegistrationFilter->SetInitialDeformationField( NULL );
      }
    else
      {
      // Resample the field to be the same size as the fixed image
      // at the current level
      m_FieldExpander->SetInput( tempField );
      
      typename FloatImageType::Pointer fi = 
        m_FixedImagePyramid->GetOutput( fixedLevel );
      m_FieldExpander->SetSize( 
        fi->GetLargestPossibleRegion().GetSize() );
      m_FieldExpander->SetOutputStartIndex(
        fi->GetLargestPossibleRegion().GetIndex() );
      m_FieldExpander->SetOutputOrigin( fi->GetOrigin() );
      m_FieldExpander->SetOutputSpacing( fi->GetSpacing());
      m_FieldExpander->SetOutputDirection( fi->GetDirection());

      m_FieldExpander->UpdateLargestPossibleRegion();
      m_FieldExpander->SetInput( NULL );
      tempField = m_FieldExpander->GetOutput();
      tempField->DisconnectPipeline();

      m_RegistrationFilter->SetInitialDeformationField( tempField );

      }

    // setup registration filter and pyramids 
    m_RegistrationFilter->SetMovingImage( m_MovingImagePyramid->GetOutput(movingLevel) );
    m_RegistrationFilter->SetFixedImage( m_FixedImagePyramid->GetOutput(fixedLevel) );

    m_RegistrationFilter->SetNumberOfIterations(
      m_NumberOfIterations[m_CurrentLevel] );

    // cache shrink factors for computing the next expand factors.
    lastShrinkFactorsAllOnes = true;
    for( unsigned int idim = 0; idim < ImageDimension; idim++ )
      {
      if ( m_FixedImagePyramid->GetSchedule()[fixedLevel][idim] > 1 )
        {
        lastShrinkFactorsAllOnes = false;
        break;
        }
      }

    // compute new deformation field
    m_RegistrationFilter->UpdateLargestPossibleRegion();
    tempField = m_RegistrationFilter->GetOutput();
    tempField->DisconnectPipeline();

    // Increment level counter.  
    m_CurrentLevel++;
    movingLevel = vnl_math_min( (int) m_CurrentLevel, 
                                (int) m_MovingImagePyramid->GetNumberOfLevels() );
    fixedLevel = vnl_math_min( (int) m_CurrentLevel, 
                               (int) m_FixedImagePyramid->GetNumberOfLevels() );

    // Invoke an iteration event.
    this->InvokeEvent( IterationEvent() );

    // We can release data from pyramid which are no longer required.
    if ( movingLevel > 0 )
      {
      m_MovingImagePyramid->GetOutput( movingLevel - 1 )->ReleaseData();
      }
    if( fixedLevel > 0 )
      {
      m_FixedImagePyramid->GetOutput( fixedLevel - 1 )->ReleaseData();
      }

    } // while not Halt()

  if( !lastShrinkFactorsAllOnes )
    {
    // Some of the last shrink factors are not one
    // graft the output of the expander filter to
    // to output of this filter

    // resample the field to the same size as the fixed image
    m_FieldExpander->SetInput( tempField );
    m_FieldExpander->SetSize( 
      fixedImage->GetLargestPossibleRegion().GetSize() );
    m_FieldExpander->SetOutputStartIndex(
      fixedImage->GetLargestPossibleRegion().GetIndex() );
    m_FieldExpander->SetOutputOrigin( fixedImage->GetOrigin() );
    m_FieldExpander->SetOutputSpacing( fixedImage->GetSpacing());
    m_FieldExpander->SetOutputDirection( fixedImage->GetDirection());

    m_FieldExpander->UpdateLargestPossibleRegion();
    this->GraftOutput( m_FieldExpander->GetOutput() );
    }
  else
    {
    // all the last shrink factors are all ones
    // graft the output of registration filter to
    // to output of this filter
    this->GraftOutput( tempField );
    }

  // Release memory
  m_FieldExpander->SetInput( NULL );
  m_FieldExpander->GetOutput()->ReleaseData();
  m_RegistrationFilter->SetInput( NULL );
  m_RegistrationFilter->GetOutput()->ReleaseData();

}


template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
void
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::StopRegistration()
{
  m_RegistrationFilter->StopRegistration();
  m_StopRegistrationFlag = true;
}

template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
bool
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::Halt()
{
  // Halt the registration after the user-specified number of levels
  if (m_NumberOfLevels != 0)
    {
    this->UpdateProgress( static_cast<float>( m_CurrentLevel ) /
                          static_cast<float>( m_NumberOfLevels ) );
    }

  if ( m_CurrentLevel >= m_NumberOfLevels )
    {
    return true;
    }
  if ( m_StopRegistrationFlag )
    {
    return true;
    }
  else
    { 
    return false; 
    }

}


template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
void
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::GenerateOutputInformation()
{

  typename DataObject::Pointer output;

  if( this->GetInput(0) )
    {
    // Initial deformation field is set.
    // Copy information from initial field.
    this->Superclass::GenerateOutputInformation();

    }
  else if( this->GetFixedImage() )
    {
    // Initial deforamtion field is not set. 
    // Copy information from the fixed image.
    for (unsigned int idx = 0; idx < 
           this->GetNumberOfOutputs(); ++idx )
      {
      output = this->GetOutput(idx);
      if (output)
        {
        output->CopyInformation(this->GetFixedImage());
        }  
      }

    }

}


template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
void
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::GenerateInputRequestedRegion()
{

  // call the superclass's implementation
  Superclass::GenerateInputRequestedRegion();

  // request the largest possible region for the moving image
  MovingImagePointer movingPtr = 
    const_cast< MovingImageType * >( this->GetMovingImage() );
  if( movingPtr )
    {
    movingPtr->SetRequestedRegionToLargestPossibleRegion();
    }
  
  // just propagate up the output requested region for
  // the fixed image and initial deformation field.
  DeformationFieldPointer inputPtr = 
    const_cast< DeformationFieldType * >( this->GetInput() );
  DeformationFieldPointer outputPtr = this->GetOutput();
  FixedImagePointer fixedPtr = 
    const_cast< FixedImageType *>( this->GetFixedImage() );

  if( inputPtr )
    {
    inputPtr->SetRequestedRegion( outputPtr->GetRequestedRegion() );
    }

  if( fixedPtr )
    {
    fixedPtr->SetRequestedRegion( outputPtr->GetRequestedRegion() );
    }

}


template <class TFixedImage, class TMovingImage, class TDeformationField, class TRealType>
void
MultiResolutionPDEDeformableRegistration<TFixedImage,TMovingImage,TDeformationField,TRealType>
::EnlargeOutputRequestedRegion(
  DataObject * ptr )
{
  // call the superclass's implementation
  Superclass::EnlargeOutputRequestedRegion( ptr );

  // set the output requested region to largest possible.
  DeformationFieldType * outputPtr;
  outputPtr = dynamic_cast<DeformationFieldType*>( ptr );

  if( outputPtr )
    {
    outputPtr->SetRequestedRegionToLargestPossibleRegion();
    }

}


} // end namespace itk

#endif